Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press367Pediatric OncologyПЕДИАТРИЧЕСКАЯ ОНКОЛОГИЯThe treatment of children with synovial sarcomaЛечение синовиальной саркомы у пациентов детского возрастаKhestanovD. B.ХестановД. Б.
Russian Federation

Moscow

г. Москва

hestanov@mail.ruSenzhapovaE. R.СенжаповаЭ. Р.
Russian Federation

Moscow

г. Москва

RomantsovaO. M.РоманцоваО. М.
Russian Federation

Moscow

г. Москва

KochievaV. V.КочиеваВ. В.
Russian Federation

Moscow

г. Москва

DzampaevA. Z.ДзампаевА. З.
Russian Federation

Moscow

г. Москва

AlievM. D.АлиевМ. Д.
Russian Federation

Moscow

г. Москва

Institute of Paediatric Oncology and Hematology N.N. Blokhin Cancer Research Center, Ministry of Health of Russian FederationНИИ ДОГ «ФГБУ РОНЦ им. Н.Н. Блохина»221020168360662201202222012022Copyright ©; 2016, Khestanov D.B., Senzhapova E.R., Romantsova O.M., Kochieva V.V., Dzampaev A.Z., Aliev M.D.Copyright ©; 2016, Хестанов Д.Б., Сенжапова Э.Р., Романцова О.М., Кочиева В.В., Дзампаев А.З., Алиев М.Д.2016Khestanov D.B., Senzhapova E.R., Romantsova O.M., Kochieva V.V., Dzampaev A.Z., Aliev M.D.Хестанов Д.Б., Сенжапова Э.Р., Романцова О.М., Кочиева В.В., Дзампаев А.З., Алиев М.Д.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/367

Improvement of the results of treatment of synovial sarcoma in children and adolescents is the target of this study. 38 children and adolescents at the mean age of 10,5±3,7 years (18 males, 20 females) with synovial sarcoma were treated between 1999 and 2014 years in the Research Institution of Pediatric Oncology in the Russian Cancer Center. Treatment included chemotherapy, radiotherapy and surgical operation. The toxicity of intensive chemotherapy was reduced by support of peripheral blood stem cells in the investigation group of patients. 2-year disease-free survival was 66,1±11,3%, overall 5-year survival –75,6±10,6%.

В настоящей работе проведен анализ результатов лечения 38 (18 мальчиков и 20 девочек) пациентов, средний возраст 10,5±3,7 года, с синовиальной саркомой различной локализации, находившихся на обследовании и получавших лечение в период с 1999 по 2014 г. в условиях НИИ ДОГ ГУ РОНЦ им. Н.Н. Блохина. Результаты терапии оценивались на 31.07.2016 г. Анализируемая группа получила лечение по схеме: полихимиотерапия (ПХТ) препаратами вепезид 100 мг/м2 в 1–5-й дни, циклофосфан 400 мг/м2 в 1–5-й дни, карбоплатин 500 мг/м2 в 4-й день от 4 до 8 курсов; лучевая терапия (ЛТ) на первичный очаг в суммарной очаговой дозе (СОД) 45–50 Гр, по показаниям – крупнопольное облучение легких в СОД 12 Гр и хирургическое вмешательство в разных объемах, преимущественно органосохраняющего характера. Всем больным проводилась реинфузия субтрансплантационных доз аутологичных периферических стволовых клеток (ПСК). Общая 2-летняя выживаемость пациентов составила 75,6±10,6%, безрецидивная 2-летняя выживаемость – 66,1±11,3%.

synovial sarcomapediatric oncologychemotherapyсиновиальная саркомадетская онкологияхимиотерапия1. Васильев Н.В. Синовиальная саркома. Оценка прогноза. Сибирский онкологический журнал. 2010, № 1, с. 73-78.Васильев Н.В. Синовиальная саркома. Оценка прогноза. Сибирский онкологический журнал. 2010, № 1, с. 73-78.2. Brecht I.B., Ferrari A. et al. Grossly-resected synovial sarcoma treated by the German and Italian Pediatric Soft Tissue Sarcoma Cooperative Groups: discussion on the role of adjuvant therapies. Pediatr. Blood Cancer. 2006, v. 46 (1), p. 11-17.Brecht I.B., Ferrari A. et al. Grossly-resected synovial sarcoma treated by the German and Italian Pediatric Soft Tissue Sarcoma Cooperative Groups: discussion on the role of adjuvant therapies. Pediatr. Blood Cancer. 2006, v. 46 (1), p. 11-17.3. Casali P.G., Jost L., Sleijfer S. et al. ESMO Guidelines Working Group. Soft tissue sarcomas: ESMO clinical recommendations. Ann. Oncol. 2008, v. 19 (suppl. 2), p. ii89-ii93.Casali P.G., Jost L., Sleijfer S. et al. ESMO Guidelines Working Group. Soft tissue sarcomas: ESMO clinical recommendations. Ann. Oncol. 2008, v. 19 (suppl. 2), p. ii89-ii93.4. Casanova M., Meazza C. et al. Soft-tissue sarcomas of the extremities in patients of pediatric age. J. Child Orthop. 2007, v. 1 (3), p. 195-203.Casanova M., Meazza C. et al. Soft-tissue sarcomas of the extremities in patients of pediatric age. J. Child Orthop. 2007, v. 1 (3), p. 195-203.5. Eilber F.C., Brennan M.F., Eilber F.R. et al. Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann. Surg. 2007, v. 246, p. 105-113.Eilber F.C., Brennan M.F., Eilber F.R. et al. Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Ann. Surg. 2007, v. 246, p. 105-113.6. Ferrari A., Casanova M. et al. Synovial sarcoma: Report of a series of 25 consecutive children from a single institution. Med. and Pediat. Oncol. 1999, v. 32 (1), p. 32-37.Ferrari A., Casanova M. et al. Synovial sarcoma: Report of a series of 25 consecutive children from a single institution. Med. and Pediat. Oncol. 1999, v. 32 (1), p. 32-37.7. Ferrari A., Gronchi A., Casanova M. et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer. 2004, v. 101, p. 627-634.Ferrari A., Gronchi A., Casanova M. et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer. 2004, v. 101, p. 627-634.8. Gofman A., Issakov J. et al. Synovial sarcoma of the extremities and trunk: a long-lasting disease. Oncol. Rep. 2007, v. 18 (6), p. 1577-1581.Gofman A., Issakov J. et al. Synovial sarcoma of the extremities and trunk: a long-lasting disease. Oncol. Rep. 2007, v. 18 (6), p. 1577-1581.9. Guadagnolo B.A., Zagars G.K. et al. Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2007, v. 69 (4), p. 1173-1180. Epub 2007 Aug. 6.Guadagnolo B.A., Zagars G.K. et al. Long-term outcomes for synovial sarcoma treated with conservation surgery and radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2007, v. 69 (4), p. 1173-1180. Epub 2007 Aug. 6.10. Hasegawa T., Yamamoto S., Yokoyama R. et al. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer. 2002, v. 95, p. 843-851.Hasegawa T., Yamamoto S., Yokoyama R. et al. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer. 2002, v. 95, p. 843-851.11. Hawkins D., Felgenhauer J. et al. Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas. Cancer. 2002, v. 95 (6), p. 1356-1365.Hawkins D., Felgenhauer J. et al. Peripheral blood stem cell support reduces the toxicity of intensive chemotherapy for children and adolescents with metastatic sarcomas. Cancer. 2002, v. 95 (6), p. 1356-1365.12. Kilpatrick S.E., Bergman S. et al. The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas. Modern Pathology. 2006, v. 19, p. 815-819.Kilpatrick S.E., Bergman S. et al. The usefulness of cytogenetic analysis in fine needle aspirates for the histologic subtyping of sarcomas. Modern Pathology. 2006, v. 19, p. 815-819.13. Ladenstein R., Treuner J. et al. Synovial sarcoma of childhood and adolescence. Report of the German CWS-81 study. Cancer. 1993, v. 71, p. 3647-3655.Ladenstein R., Treuner J. et al. Synovial sarcoma of childhood and adolescence. Report of the German CWS-81 study. Cancer. 1993, v. 71, p. 3647-3655.14. Lewis J.J., Antonescu C.R. et al. Synovial Sarcoma: A Multevariate Analysis of Prognostic Factors in 112 Patients with Primary Localized Tumors of the Extremity. J. Clin. Oncol. 2000, v. 18 (10), p. 2087-2094.Lewis J.J., Antonescu C.R. et al. Synovial Sarcoma: A Multevariate Analysis of Prognostic Factors in 112 Patients with Primary Localized Tumors of the Extremity. J. Clin. Oncol. 2000, v. 18 (10), p. 2087-2094.15. Miser J.S., Pappo A.S., Triche T.J. et al. Other soft tissue sarcomas of childhood. In: Pizzo P.A., Poplack D.G., editors. Principles and practice of pediatric oncology. Philadelphia, PA: Lippincott Williams&Wilkins. 2002, p. 1017-1050.Miser J.S., Pappo A.S., Triche T.J. et al. Other soft tissue sarcomas of childhood. In: Pizzo P.A., Poplack D.G., editors. Principles and practice of pediatric oncology. Philadelphia, PA: Lippincott Williams&Wilkins. 2002, p. 1017-1050.16. Okcu M.F., Despa S. et al. Synovial sarcoma in children and adolescents: thirty three years of experience with multimodal therapy. Med. Pediatr. Oncol. 2001, v. 37 (2), p. 90-96.Okcu M.F., Despa S. et al. Synovial sarcoma in children and adolescents: thirty three years of experience with multimodal therapy. Med. Pediatr. Oncol. 2001, v. 37 (2), p. 90-96.17. Okcu M.F., Munsell M. et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J. Clin. Oncol. 2003, v. 21 (8), p. 1602-1611.Okcu M.F., Munsell M. et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J. Clin. Oncol. 2003, v. 21 (8), p. 1602-1611.18. Palmerini E., Staals E.L. et al. Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution. Сancer. 2009, v. 115 (13), p. 2988-2998.Palmerini E., Staals E.L. et al. Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution. Сancer. 2009, v. 115 (13), p. 2988-2998.19. Pisters P.W., Sullivan B.O., Maki R.G. Evidence-based recommendations for local therapy for soft tissue sarcomas. J. Clin. Oncol. 2007, v. 25, p. 1003-1008.Pisters P.W., Sullivan B.O., Maki R.G. Evidence-based recommendations for local therapy for soft tissue sarcomas. J. Clin. Oncol. 2007, v. 25, p. 1003-1008.20. Ulmer C., Kettelhack C. et al. Synovial sarcoma of the extremities. Results of surgical and multimodal therapy. Chirurg. 2003, v. 74 (4), p. 370-374.Ulmer C., Kettelhack C. et al. Synovial sarcoma of the extremities. Results of surgical and multimodal therapy. Chirurg. 2003, v. 74 (4), p. 370-374.21. Weiss S.W., Goldblum J. Malignant soft tissue tumors of uncertain type. In: Weiss S.W., Goldblum J.R., editors. Enzingerand Weiss soft tissue tumors. St. Louis, Missouri: CV Mosby. 2001, p. 1483-1571.Weiss S.W., Goldblum J. Malignant soft tissue tumors of uncertain type. In: Weiss S.W., Goldblum J.R., editors. Enzingerand Weiss soft tissue tumors. St. Louis, Missouri: CV Mosby. 2001, p. 1483-1571.22. Aydin O., Ersoz C., Ozbarlas S., Seydaoglu G. Assessment of proliferative activity in soft tissue sarcomas showing PCNA and Ki-67 reactivity immunohistochemically. Turk. J. Med. Sci. 2000, v. 30. p. 261-269.Aydin O., Ersoz C., Ozbarlas S., Seydaoglu G. Assessment of proliferative activity in soft tissue sarcomas showing PCNA and Ki-67 reactivity immunohistochemically. Turk. J. Med. Sci. 2000, v. 30. p. 261-269.23. Baptista A.M., de Camargo O.P., Croci А.Т. et al. Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance. Clinics. 2006, v. 61 (5), p. 381-386.Baptista A.M., de Camargo O.P., Croci А.Т. et al. Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance. Clinics. 2006, v. 61 (5), p. 381-386.24. Billings S.D., Meisner L.F., Cummings O.W., Tejada E. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X; 18 translocation by fluorescence in situ hybridization. Mod. Pathol. 2000, v. 13 (1), p. 68-76.Billings S.D., Meisner L.F., Cummings O.W., Tejada E. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X; 18 translocation by fluorescence in situ hybridization. Mod. Pathol. 2000, v. 13 (1), p. 68-76.25. Cormier J.N., Pollock R.E. Soft tissue sarcomas. Cancer J. Clin. 2004, v. 54 (94), p. 1-16.Cormier J.N., Pollock R.E. Soft tissue sarcomas. Cancer J. Clin. 2004, v. 54 (94), p. 1-16.26. Deyrup А.Т., Haydon R.C., Huo D. et al. Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity. Cancer. 2003, v. 98, p. 805-813.Deyrup А.Т., Haydon R.C., Huo D. et al. Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity. Cancer. 2003, v. 98, p. 805-813.27. Fletcher C.D.M., Unni К.К., Mertens F. eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; World Health Organization Classification of Tumors. 2002, v. 5.Fletcher C.D.M., Unni К.К., Mertens F. eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; World Health Organization Classification of Tumors. 2002, v. 5.28. Frazier A.A., Franks T.J., Pugatch R.D., Galvin J.R. From the Archives of the AFIP. Pleuropulmonary synovial sarcoma. Radiographics. 2006, v. 26 (3), p. 923-941.Frazier A.A., Franks T.J., Pugatch R.D., Galvin J.R. From the Archives of the AFIP. Pleuropulmonary synovial sarcoma. Radiographics. 2006, v. 26 (3), p. 923-941.29. Gabilondo F., Rodriguez F., Mohar A. et al. Primary synovial sarcoma of the kidney: corroboration with in situ polymerase chain reaction . Ann. Diagn. Pathol. 2008, v. 12 (2), p. 134-137.Gabilondo F., Rodriguez F., Mohar A. et al. Primary synovial sarcoma of the kidney: corroboration with in situ polymerase chain reaction . Ann. Diagn. Pathol. 2008, v. 12 (2), p. 134-137.30. Goto Y., Kawauchi S., Ihara K. et al. The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27Kipi and cyclin E. Cancer Sci. 2003, v. 94, p. 412-417.Goto Y., Kawauchi S., Ihara K. et al. The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27Kipi and cyclin E. Cancer Sci. 2003, v. 94, p. 412-417.31. Guillou L., Benhattar J., Bonichon F. et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J. Clin. Oncol. 2004, v. 22, p. 4040-4050.Guillou L., Benhattar J., Bonichon F. et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J. Clin. Oncol. 2004, v. 22, p. 4040-4050.32. Hajdu S.I., Shiu M.H., Fortner J.G. Tendosynovial sarcoma: a clinical pathological study of 136 cases. Cancer. 1977, v. 39, p. 1201-1217.Hajdu S.I., Shiu M.H., Fortner J.G. Tendosynovial sarcoma: a clinical pathological study of 136 cases. Cancer. 1977, v. 39, p. 1201-1217.33. Kawai A., Woodruff J., Healey J.H. et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N. Engl. J. Med. 1998, v. 338, p. 153-160.Kawai A., Woodruff J., Healey J.H. et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N. Engl. J. Med. 1998, v. 338, p. 153-160.34. Kilpatrick S.E., Geisinger K.R., King T.S. et al. Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. Mod. Pathol. 2001, v. 14, p. 1277-1283.Kilpatrick S.E., Geisinger K.R., King T.S. et al. Clinicopathologic analysis of HER-2/neu immunoexpression among various histologic subtypes and grades of osteosarcoma. Mod. Pathol. 2001, v. 14, p. 1277-1283.35. Lee T.J., Chung J.H., Joh J.S. et al. Primary mediastinal synovial sarcoma. J. Lung Cancer. 2008, v. 7 (1), p. 29-33.Lee T.J., Chung J.H., Joh J.S. et al. Primary mediastinal synovial sarcoma. J. Lung Cancer. 2008, v. 7 (1), p. 29-33.36. Lewis J.J., Antonescu C.R., Leung D.H.Y. et al. Synovial sarcoma: A multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity. J. Clin. Oncol. 2000, v. 18, p. 2087-2094.Lewis J.J., Antonescu C.R., Leung D.H.Y. et al. Synovial sarcoma: A multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity. J. Clin. Oncol. 2000, v. 18, p. 2087-2094.37. Lopes J.M. Pathogenesis and prognostic parameters in synovial sarcoma. Rev. Esp. Patol. 2004, Short course 8, p. 430.Lopes J.M. Pathogenesis and prognostic parameters in synovial sarcoma. Rev. Esp. Patol. 2004, Short course 8, p. 430.38. Machen S.K., Easley K.A., Goldblum J.R. Synovial sarcoma of the extremities: a clinicopathologic study of 34 cases, including semi-quantitative analysis of spindled, epithelial and poorly differentiated areas. Am. J. Surg. Pathol. 1999, v. 23, p. 268-275.Machen S.K., Easley K.A., Goldblum J.R. Synovial sarcoma of the extremities: a clinicopathologic study of 34 cases, including semi-quantitative analysis of spindled, epithelial and poorly differentiated areas. Am. J. Surg. Pathol. 1999, v. 23, p. 268-275.39. Morrison С., Wakely P.E. Jr., Ashman C.J. et al. Cystic synovial sarcoma. Ann. Diagn. Pathol. 2001, v. 5, p. 48-56.Morrison С., Wakely P.E. Jr., Ashman C.J. et al. Cystic synovial sarcoma. Ann. Diagn. Pathol. 2001, v. 5, p. 48-56.40. Mullen J.R., Zagars G.K. Synovial sarcoma outcome following conservation surgery and radiotherapy. Radiother. Oncol. 1994, v. 33, p. 23-30.Mullen J.R., Zagars G.K. Synovial sarcoma outcome following conservation surgery and radiotherapy. Radiother. Oncol. 1994, v. 33, p. 23-30.41. Nagayama S., Katagiri Т., Tsunoda Т. et al. Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res. 2002, v. 62, p. 5859-5866.Nagayama S., Katagiri Т., Tsunoda Т. et al. Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res. 2002, v. 62, p. 5859-5866.42. Ahmed Q., Tien S.L. et al. Primary pleural synovial sarcoma. Arch. Pathol. Lab. Med. 2003, v. 127, p. 85-90.Ahmed Q., Tien S.L. et al. Primary pleural synovial sarcoma. Arch. Pathol. Lab. Med. 2003, v. 127, p. 85-90.43. Oda Y., Hashimoto H., Takeshita S., Tsuneyoshi M. The prognostic value of immunohistochemical staining for proliferating cell nuclear antigen in synovial sarcoma. Cancer. 1993, v. 72, p. 478-485.Oda Y., Hashimoto H., Takeshita S., Tsuneyoshi M. The prognostic value of immunohistochemical staining for proliferating cell nuclear antigen in synovial sarcoma. Cancer. 1993, v. 72, p. 478-485.44. Oda Y., Hashimoto H., Tsuneyoshi M., Takeshita S. Survival in synovial sarcoma. A multivariate study of prognostic factors with special emphasis on the comparison between early death and long-term survival. Am. J. Surg. Pathol. 1993, v. 17, p. 35-44.Oda Y., Hashimoto H., Tsuneyoshi M., Takeshita S. Survival in synovial sarcoma. A multivariate study of prognostic factors with special emphasis on the comparison between early death and long-term survival. Am. J. Surg. Pathol. 1993, v. 17, p. 35-44.45. Okcu M.F., Munsell M., Treuner J. et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J. Clin. Oncol. 2003, v. 21 (8), p. 1602-1611.Okcu M.F., Munsell M., Treuner J. et al. Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J. Clin. Oncol. 2003, v. 21 (8), p. 1602-1611.46. Rooser B., Willen H., Hugoson A., Rydholm A. Prognostic factors in synovial sarcoma. Cancer. 1989, v. 63, p. 2182-2185.Rooser B., Willen H., Hugoson A., Rydholm A. Prognostic factors in synovial sarcoma. Cancer. 1989, v. 63, p. 2182-2185.47. Sato O., Wada Т., Kawai A. et al. Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas. Cancer. 2005, v. 103, p. 1881-1890.Sato O., Wada Т., Kawai A. et al. Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas. Cancer. 2005, v. 103, p. 1881-1890.48. Scmidt D., Thum P., Harms D., Treuner J. Synovial sarcoma in children and adolescents. A report from the Kiel Pediatric Tumor Registry. Cancer. 1991, v. 67, p. 1667-1672.Scmidt D., Thum P., Harms D., Treuner J. Synovial sarcoma in children and adolescents. A report from the Kiel Pediatric Tumor Registry. Cancer. 1991, v. 67, p. 1667-1672.49. Siegel H.J., Sessions W., Cassillas M.A. Jr. et al. Synovial sarcoma: Clinicopathologic features, treatment, and prognosis. Orthopedics. 2007, v. 30, p. 1020-1029.Siegel H.J., Sessions W., Cassillas M.A. Jr. et al. Synovial sarcoma: Clinicopathologic features, treatment, and prognosis. Orthopedics. 2007, v. 30, p. 1020-1029.50. Singer S., Baldini E.H., Demetri G.D. et al. Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J. Clin. Oncol. 1996, v. 14, p. 1201-1208.Singer S., Baldini E.H., Demetri G.D. et al. Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival. J. Clin. Oncol. 1996, v. 14, p. 1201-1208.51. Skubitz K.M., Dadamo D.R. Sarcoma. Mayo Clin. Proc. 2007, v. 82 (11), p. 1409-1432.Skubitz K.M., Dadamo D.R. Sarcoma. Mayo Clin. Proc. 2007, v. 82 (11), p. 1409-1432.52. Skytting В., Meis-Kindblom J.M., Larsson O. et al. Synovial sarcoma – identification of favorable and unfavorable histologic types: a Scandinavian sarcoma group study of 104 cases. Acta Orthop. Scand. 1999, v. 70, p. 543-554.Skytting В., Meis-Kindblom J.M., Larsson O. et al. Synovial sarcoma – identification of favorable and unfavorable histologic types: a Scandinavian sarcoma group study of 104 cases. Acta Orthop. Scand. 1999, v. 70, p. 543-554.53. Spillane A.J., A’Hern R., Judson I.R. et al. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J. Clin. Oncol. 2000, v. 18, p. 3794-3803.Spillane A.J., A’Hern R., Judson I.R. et al. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J. Clin. Oncol. 2000, v. 18, p. 3794-3803.54. Spurrell E.L., Fisher C., Thomas J.M., Judson I.R. Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital. Ann. Oncol. 2005, v. 16, p. 437-444.Spurrell E.L., Fisher C., Thomas J.M., Judson I.R. Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital. Ann. Oncol. 2005, v. 16, p. 437-444.55. Thompson R.C. Jr., Garg A., Goswitz J. et al. Synovial sarcoma. Large size predicts poor outcome. Clin. Orthop. Relat. Res. 2000, v. 373, p. 18-24.Thompson R.C. Jr., Garg A., Goswitz J. et al. Synovial sarcoma. Large size predicts poor outcome. Clin. Orthop. Relat. Res. 2000, v. 373, p. 18-24.56. Ueda Т., Aozasa K., Tsujimoto M. et al. Prognostic significance of mast cells in soft tissue sarcoma. Cancer. 1989, v. 63, p. 1607-1611.Ueda Т., Aozasa K., Tsujimoto M. et al. Prognostic significance of mast cells in soft tissue sarcoma. Cancer. 1989, v. 63, p. 1607-1611.57. Varela-Duran J., Enzinger F.M. Calcifying synovial sarcoma. Cancer. 1982, v. 50, p. 345-352.Varela-Duran J., Enzinger F.M. Calcifying synovial sarcoma. Cancer. 1982, v. 50, p. 345-352.58. Weiss S.W., Goldblum J.R., Enzinger F.M. Enzinger and Weiss’s Soft Tissue Tumors. 4-еd. St. Louis: Mosby Co. 2001.Weiss S.W., Goldblum J.R., Enzinger F.M. Enzinger and Weiss’s Soft Tissue Tumors. 4-еd. St. Louis: Mosby Co. 2001.59. Wen P., Prasad M.L. Synovial Sarcoma With Rhabdoid Features. Arch. Pathol. Lab. Med. 2003, v. 127 (10), p. 1391-1392.Wen P., Prasad M.L. Synovial Sarcoma With Rhabdoid Features. Arch. Pathol. Lab. Med. 2003, v. 127 (10), p. 1391-1392.60. White B.E., Kaplan A., Lopez-Terrada D.H. et al. Monophasic synovial sarcoma arising in the vulva. Arch. Pathol. Lab. Med. 2008, v. 132, p. 698-702.White B.E., Kaplan A., Lopez-Terrada D.H. et al. Monophasic synovial sarcoma arising in the vulva. Arch. Pathol. Lab. Med. 2008, v. 132, p. 698-702.61. Wright P.H., Sim F.H., Soule E.H., Taylor W.F. Synovial sarcoma. J. Bone Joint Surg. Am. 1982, v. 64, p. 112-122.Wright P.H., Sim F.H., Soule E.H., Taylor W.F. Synovial sarcoma. J. Bone Joint Surg. Am. 1982, v. 64, p. 112-122.