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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Bone and soft tissue sarcomas, tumors of the skin</journal-id><journal-title-group><journal-title xml:lang="en">Bone and soft tissue sarcomas, tumors of the skin</journal-title><trans-title-group xml:lang="ru"><trans-title>Саркомы костей, мягких тканей и опухоли кожи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4614</issn><issn publication-format="electronic">2782-3687</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">400</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>TUMORS OF THE SKIN</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОПУХОЛИ КОЖИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Merkel carcinoma. Clinical behavior and prognostic factors</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности заболевания и факторы прогноза</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vasiliev</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Васильев</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nv-vasilev@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zheravin</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Жеравин</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tiukalov</surname><given-names>U. I.</given-names></name><name xml:lang="ru"><surname>Тюкалов</surname><given-names>Ю. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tomsk Cancer Research Center</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Томcкий НИИ онкологии»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-11-22" publication-format="electronic"><day>22</day><month>11</month><year>2015</year></pub-date><volume>7</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>63</fpage><lpage>68</lpage><history><date date-type="received" iso-8601-date="2022-01-22"><day>22</day><month>01</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-01-22"><day>22</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Vasiliev N.V., Zheravin A.A., Tiukalov U.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Васильев Н.В., Жеравин А.А., Тюкалов Ю.И.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Vasiliev N.V., Zheravin A.A., Tiukalov U.I.</copyright-holder><copyright-holder xml:lang="ru">Васильев Н.В., Жеравин А.А., Тюкалов Ю.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://sarbon.abvpress.ru/jour/article/view/400">https://sarbon.abvpress.ru/jour/article/view/400</self-uri><abstract xml:lang="en"><p>Merkel-cell carcinoma is a rare and highly aggressive skin cancer. It is characterized by a variety of histological subtypes and features that cause difficulties in morphological diagnosis. Estimation of Merkel-cell carcinoma prognosis is one of the priorities. Histological, immunohistochemical and clinical characteristics of the tumor are prognostic factors in Merkel-cell carcinoma.</p></abstract><trans-abstract xml:lang="ru"><p>Карцинома Меркеля – редкая и крайне агрессивная опухоль кожи, отличающаяся гистологическим многообразием, обусловливающим трудности морфологической диагностики. Оценка прогноза карциномы Меркеля является одной из приоритетных задач. Факторами прогноза выступают гистологические, иммуногистохимические, клинические характеристики опухоли.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Merkelcarcinoma</kwd><kwd>prognosticfactors</kwd><kwd>histologicsubtype</kwd><kwd>differential diagnosis</kwd><kwd>immunohistochemistry</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>карцинома Меркеля</kwd><kwd>факторы прогноза</kwd><kwd>гистологический субтип</kwd><kwd>дифференциальная диагностика</kwd><kwd>иммуногистохимическое исследование</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Andea A.A., Coit D.G., Amin B., Busam K.J. Merkel Cell Carcinoma. Histologic Features and Prognosis. Cancer. 2008, v. 113, p. 2549-2558.</mixed-citation><mixed-citation xml:lang="ru">Andea A.A., Coit D.G., Amin B., Busam K.J. Merkel Cell Carcinoma. Histologic Features and Prognosis. 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