Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press419TUMORS OF THE SKINОПУХОЛИ КОЖИIsolated regional limb perfusion in the treatment of patients with melanoma of the skinИзолированная регионарная перфузия в комбинированном лечении пациентов с меланомой кожи конечностейPetrochenkoN. S.ПетроченкоН. С.
Russian Federation

Moscow

г. Москва

petrochenko-@nikolayy.rambler.ruN.N. Blokhin Russian Cancer Research CenterФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина»230420157212162301202223012022Copyright ©; 2015, Petrochenko N.S.Copyright ©; 2015, Петроченко Н.С.2015Petrochenko N.S.Петроченко Н.С.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/419

It was performed an analysis of published data on possible methods of isolated regional perfusion (IRP) in the treatment of locally advanced extremity melanoma. It is shown that the method is becoming more common as superior to other methods in the treatment of tumors of this embodiment. It was found that when using IRP average five-year survival without signs of the disease is 39%, while in patients underwent IRP was unresectable tumor with a poor prognosis. In regard to safety performance it demonstrated that IRP is rarely accompanied by severe manifestations of local or systemic toxicity. These data confirm the safety and the possibility of using IRP method in a clinical setting. The study of patients after IRP quality of life showed an increase in its level after treatment by this method. There are reports on the efficacy of the method in combination with surgical treatment of the tumor. However, to date there is no evidence that adjuvant IRP extends the life of patients with melanoma, indicating a need for further research possibilities of this method.

Выполнен анализ литературных данных о возможностях метода изолированной регионарной перфузии (ИРП) конечностей в лечении местнораспространенной меланомы. Показано, что метод получает все большее распространение, поскольку превосходит по эффективности другие методы при лечении этого варианта опухоли. Установлено, что при использовании ИРП средняя пятилетняя выживаемость без признаков заболевания составляет 39%, при этом у пациентов, подвергшихся ИРП, была нерезектабельная опухоль с плохим прогнозом. В отношении характеристики безопасности показано, что ИРП редко сопровождается тяжелыми проявлениями местной или системной токсичности. Эти данные подтверждают безопасность ИРП и возможность применения метода в клинических условиях. Результаты исследования качества жизни пациентов после ИРП свидетельствуют о повышении его уровня после лечения этим методом. Имеются сообщения об эффективности применения метода в комплексе с хирургическим лечением опухоли. Тем не менее до настоящего времени отсутствуют доказательства того, что адъювантная ИРП продлевает срок жизни пациентов с меланомой, что свидетельствует о необходимости проведения дальнейших исследований возможностей этого метода.

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