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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Bone and soft tissue sarcomas, tumors of the skin</journal-id><journal-title-group><journal-title xml:lang="en">Bone and soft tissue sarcomas, tumors of the skin</journal-title><trans-title-group xml:lang="ru"><trans-title>Саркомы костей, мягких тканей и опухоли кожи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4614</issn><issn publication-format="electronic">2782-3687</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">57</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SOFT TISSUE SARCOMAS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>САРКОМЫ МЯГКИХ ТКАНЕЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">New in the classification of soft tissue sarcomas</article-title><trans-title-group xml:lang="ru"><trans-title>Новое в классификации сарком мягких тканей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Manikaylo</surname><given-names>A. E.</given-names></name><name xml:lang="ru"><surname>Маникайло</surname><given-names>А. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>7717271@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Burov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Буров</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bokhyan</surname><given-names>B. Y.</given-names></name><name xml:lang="ru"><surname>Бохян</surname><given-names>Б. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kharatishvili</surname><given-names>T. K.</given-names></name><name xml:lang="ru"><surname>Харатишвили</surname><given-names>Т. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">FSBI «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-04-16" publication-format="electronic"><day>16</day><month>04</month><year>2019</year></pub-date><volume>11</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>15</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2021-04-16"><day>16</day><month>04</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Manikaylo A.E., Burov D.A., Bokhyan B.Y., Kharatishvili T.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Маникайло А.Е., Буров Д.А., Бохян Б.Ю., Харатишвили Т.К.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Manikaylo A.E., Burov D.A., Bokhyan B.Y., Kharatishvili T.K.</copyright-holder><copyright-holder xml:lang="ru">Маникайло А.Е., Буров Д.А., Бохян Б.Ю., Харатишвили Т.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://sarbon.abvpress.ru/jour/article/view/57">https://sarbon.abvpress.ru/jour/article/view/57</self-uri><abstract xml:lang="en"><p>The purpose of this work is to present in Russia a modern classification for various forms of soft tissue sarcoma. Also present possible genetic aberrations for all types of tumors.</p></abstract><trans-abstract xml:lang="ru"><p>Целью данной работы является представление в России современной классификации для различных форм саркомы мягких тканей. А также обозначить возможные генетические аберрации для всех типов опухоли. Это в последующем может помочь в определении тактики дальнейшего лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>TNM-классификация</kwd><kwd>TNM-classification</kwd><kwd>staging</kwd><kwd>classification of the World Health Organization</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>стадирование</kwd><kwd>классификация Всемирной организации здравоохранения</kwd><kwd>саркома</kwd><kwd>опухоль</kwd><kwd>мягкие ткани</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Каприн АД, Старинский ВВ, Петрова ГВ. Злокачественные новообразования в России в 2017 году (заболеваемость и смертность). М.: МНИОИ им. П.А. Герцена, филиал ФГБУ «НМИЦ радиологии» Минздрава России. 2018:250.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Буров ДА, Бохян БЮ, Петроченко НС, Харатишвили ТК, Агаев ДК. Разработка системы индивидуального прогнозирования появления рецидива сарком мягких тканей. Саркомы костей, мягких тканей и опухоли кожи. М.: «Фармарус Принт Медиа». 2017;(3):3-7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Бохян БЮ, Буров ДА, Петроченко НС, Харатишвили ТК, Агаев ДК. Анализ факторов риска появления рецидивов сарком мягких тканей на основе клинико-морфологических характеристик опухоли. Саркомы костей, мягких тканей и опухоли кожи. М.: «Фармарус Принт Медиа». 2018;(1):39-46.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Феденко АА. Стратегия лекарственного лечения сарком мягких тканей. Автореферат дисс. д-ра мед. наук. М., 2016. Доступно на сайте: http://docme.ru/ghR6.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Lucchesi C, Khalifa E, Laizet Y et al. Targetable Alterations in Adult Patients With Soft-Tissue Sarcomas: Insights for Personalized Therapy. JAMA Oncol. 2018;4(10):1398-1404. PMID: 29801054.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Amin MB, Edge SB, Greene FL et al. AJCC Cancer Staging Manual, 8th edition. New York: Springer; 2017.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Брайерл ДжД, Господарович МК, Виттекинд К. TNM Классификация злокачественных опухолей. Пер. с англ. Е.А. Дуброван. Логосфера. 2018:344.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Version 2.2018, 03/27/18 © National Comprehensive Cancer Network, Inc. 2018, All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Pfeifer JD, Hill DA, O’Sullivan MJ, Dehner LP. Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics? Histopathology. 2000;37:485-500. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11122430.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Sorensen PHB, Lynch JC, Qualman SJ et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children’s oncology group. J Clin Oncol. 2002;20:2672-2679. Available at: http://www.ncbi.nlm.nih.gov/pubmed/12039929.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Dickson MA, Tap WD, Keohan ML et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well- differentiated or dedifferentiated liposarcoma. J Clin Oncol. 2013;31:2024-2028. Available at: http://www. ncbi.nlm.nih.gov/pubmed/23569312.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Dickson MA, Tap WD, Keohan ML et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified liposarcoma [abstract]. ASCO Meeting Abstracts. 2013;31:10512. Available at: http://meeting.ascopubs.org/cgi/ content/abstract/31/15_suppl/10512.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Cassier PA, Kantor G, Bonvalot S et al. Adjuvant radiotherapy for extremity and trunk wall atypical lipomatous tumor/ well-differentiated LPS (ALT/WD-LPS): a French Sarcoma Group (GSF-GETO) study. Ann Oncol. 2014;25:1854-1860. Available at: http://www.ncbi.nlm.nih.gov/pubmed/24914041.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Billing V, Mertens F, Domanski HA, Rydholm A. Deep-seated ordinary and atypical lipomas: histopathology, cytogenetics, clinical features, and outcome in 215 tumours of the extremity and trunk wall. J Bone Joint Surg Br. 2008;90:929-933. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18591605.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sommerville SMM, Patton JT, Luscombe JC et al. Clinical outcomes of deep atypical lipomas (well-differentiated lipoma-like liposarcomas) of the extremities. ANZ J Surg. 2005;75:803-806. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/16173997.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lazar AJ, Tuvin D, Hajibashi S et al. Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol. 2008;173:1518-1527. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18832571.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Domont J, Salas S, Lacroix L et al. High frequency of beta-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management. Br J Cancer. 2010;102:1032-1036. Available at: http://www.ncbi.nlm.nih.gov/pubmed/20197769.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Le Guellec S, Soubeyran I, Rochaix P et al. CTNNB1 mutation analysis is a useful tool for the diagnosis of desmoid tumors: a study of 260 desmoid tumors and 191 potential morphologic mimics. Mod Pathol. 2012;25:1551-1558. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22766794.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Colombo C, Miceli R, Lazar AJ et al. CtNnB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: An independent, multicenter validation study. Cancer. 2013;119:3696-3702. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23913621.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Mullen JT, DeLaney TF, Rosenberg AE et al. beta-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist. 2013;18:1043-1049. Available at: http://www.ncbi. nlm.nih.gov/pubmed/23960186.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Galiatsatos P, Foulkes WD. Familial adenomatous polyposis. Am J Gastroenterol 2006;101:385-398. Available at: http:// www.ncbi.nlm.nih.gov/pubmed/16454848.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Half E, Bercovich D, Rozen P Familial adenomatous polyposis. Orphanet J Rare Dis. 2009;4:22. Available at: http:// www.ncbi.nlm.nih.gov/pubmed/19822006.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Nieuwenhuis MH, Lefevre JH, Bulow S et al. Family history, surgery, and APC mutation are risk factors for desmoid tumors in familial adenomatous polyposis: an international cohort study. Dis Colon Rectum. 2011;54:1229-1234. Available at: http://www ncbi.nlm.nih.gov/pubmed/21904137.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology. 2008;53:245-266. Available at: http://www. ncbi.nlm.nih.gov/pubmed/18312355.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Janeway KA, Kim SY, Lodish M et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci USA. 2011;108:314-318. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/21173220.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Pantaleo MA, Astolfi A, Urbini M et al. Analysis of all subunits, SDHA, SDHB, SDHC, SDHD, of the succinate dehydrogenase complex in KIT/PDGFRA wild-type GIST Eur J Hum Genet. 2014;22:32-39. Available at: http://www. ncbi.nlm.nih.gov/pubmed/23612575.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Agaimy A, Terracciano LM, Dirnhofer S et al. V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours. J Clin Pathol. 2009;62:613-616. Available at: http://www.ncbi. nlm.nih.gov/pubmed/19561230.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Oudijk L, Gaal J, Korpershoek E et al. SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors. Mod Pathol. 2013;26:456-463. Available at: http://www.ncbi. nlm.nih.gov/pubmed/23174939.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Korf BR. Neurofibromatosis. Handb Clin Neurol. 2013;111:333-340. Available at: http://www.ncbi.nlm.nih. gov/pubmed/23622184.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Guillou L, Benhattar J, Bonichon F et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol. 2004;22:4040-4050. Available at: http:// www.ncbi.nlm.nih.gov/pubmed/15364967.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Ladanyi M, Antonescu CR, Leung DH et al. Impact of SYTSSX fusion type on the clinical behavior of synovial sarcoma: a multi- institutional retrospective study of 243 patients. Cancer Res. 2002;62:135-140. Available at: http://www.ncbi.nlm.nih. gov/pubmed/11782370.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Kleinerman RA, Tucker MA, Abramson DH et al. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. J Natl Cancer Inst. 2007;99:24-31. Available at: http://www.ncbi.nlm.nih.gov/pubmed/17202110.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Kleinerman RA, Schonfeld SJ, Tucker MA. Sarcomas in hereditary retinoblastoma. Clin Sarcoma Res. 2012;2:15. Available at: http://www.ncbi.nlm.nih.gov/pubmed/23036192.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Brems H, Beert E, de Ravel T, Legius E. Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Lancet Oncol. 2009;10:508-515. Available at: http://www. ncbi.nlm.nih.gov/pubmed/19410195.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Hill DA, O’Sullivan MJ, Zhu X et al. Practical application of molecular genetic testing as an aid to the surgical pathologic diagnosis of sarcomas: a prospective study. Am J Surg Pathol. 2002;26:965-977. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/12170083.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Italiano A, Di Mauro I, Rapp J et al. Clinical effect of molecular methods in sarcoma diagnosis (GENSARC): a prospective, multicentre, observational study. Lancet Oncol. 2016;17:532-538. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/26970672.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Antonescu CR, Tschernyavsky SJ, Decuseara R et al. Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res. 2001;7:3977-3987. Available at: http://www.ncbi.nlm.nih. gov/pubmed/11751490.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Antonescu CR. The role of genetic testing in soft tissue sarcoma. Histopathology. 2006;48:13-21. Available at: http:// www.ncbi.nlm.nih.gov/pubmed/16359533.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Penel N, Grosjean J, Robin YM et al. Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases. Sarcoma. 2008:459386. Available at: http://www.ncbi.nlm.nih.gov/ pubmed/18497869.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Li FP, Fraumeni JF Jr., Mulvihill JJ et al. A cancer family syndrome in twenty-four kindreds. Cancer Res. 1988;48:5358-5362. Available at: http://www.ncbi.nlm.nih. gov/pubmed/3409256.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Malkin D, Li FP, Strong LC et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233-1238. Available at: http:// www.ncbi.nlm.nih.gov/pubmed/1978757.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Nichols KE, Malkin D, Garber JE et al. Germ-line p53 mutations predispose to a wide spectrum of early-onset cancers. Cancer Epidemiol Biomarkers Prev. 2001;10:83-87. Available at: http://www.ncbi.nlm.nih.gov/pubmed/11219776.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Ognjanovic S, Olivier M, Bergemann TL, Hainaut P Sarcomas in TP53 germline mutation carriers. Cancer. 2012;118:1387-1396. Available at: http://www.ncbi.nlm.nih. gov/pubmed/21837677.</mixed-citation></ref></ref-list></back></article>
