Bone and soft tissue sarcomas, tumors of the skin

Саркомы костей, мягких тканей и опухоли кожи

2219-46142782-3687

Publishing House ABV Press

719

10.17650/2219-4614-2024-16-4-18-42

REVIEWS

ОБЗОРНЫЕ СТАТЬИ

Prognostic value of gene expression profiling in melanoma: a systematic literature review

Прогностическое значение профилирования экспрессии генов при меланоме: систематический обзор литературы

https://orcid.org/0000-0001-7150-5071

Samoilenko

I. V.

Самойленко

И. В.

Russian Federation

Igor Vyacheslavovich Samoilenko

24 Kashirskoe Shosse, Moscow 115522

Игорь Вячеславович Самойленко

115522 Москва, Каширское шоссе, 24

i.samoylenko@ronc.ru

https://orcid.org/0000-0003-2163-1752

Belenkaya

Ya. V.

Беленькая

Я. В.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

Bld. 2, 8 Trubetskaya St., Moscow 119991

115522 Москва, Каширское шоссе, 24

119991 Москва, ул. Трубецкая, 8, стр. 2

https://orcid.org/0000-0002-5487-2299

Kharkevich

G. Yu.

Харкевич

Г. Ю.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-0442-5917

Orlova

K. V.

Орлова

К. В.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-7659-6045

Mikhailova

I. N.

Михайлова

И. Н.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-9532-4264

Baryshnikov

K. A.

Барышников

К. А.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-4066-179X

Vishnevskaya

Ya. V.

Вишневская

Я. В.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-8562-6082

Demidov

L. V.

Демидов

Л. В.

Russian Federation

24 Kashirskoe Shosse, Moscow 115522

115522 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России

Sechenov University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)

01112024

164

18420102202501022025

2024

Samoilenko I.V., Belenkaya Y.V., Kharkevich G.Y., Orlova K.V., Mikhailova I.N., Baryshnikov K.A., Vishnevskaya Y.V., Demidov L.V.

Самойленко И.В., Беленькая Я.В., Харкевич Г.Ю., Орлова К.В., Михайлова И.Н., Барышников К.А., Вишневская Я.В., Демидов Л.В.

https://creativecommons.org/licenses/by/4.0

https://sarbon.abvpress.ru/jour/article/view/719

Introduction. Skin melanoma, despite having similar clinical and histological characteristics, can have different prognoses. Gene expression profiling potentially allows for more accurate risk stratification of patients.

Aim. To study prognostic test systems for assessing outcomes in patients with skin melanoma based on the analysis of primary tumors.

Materials and methods. A systematic literature review (scoping review) was conducted in accordance with PRISMA-ScR principles. The search was performed in PubMed (2008–2024). Two independent reviewers conducted the study selection and data analysis to assess concordance. The data were presented descriptively.

Results. Out of 149 identified publications, 31 studies were included in the review. The effectiveness of four test systems was evaluated, with the most frequently used being DecisionDx-Melanoma (19/31, 61.3%). This test stratifies patients by molecular classes: patients at high risk were found to have a 5.33 (±1.25) times higher likelihood of disease progression and poorer survival rates compared to lower-risk patients. No studies included data on the Russian population.

Conclusions. Gene expression profiling demonstrates high accuracy in predicting outcomes for patients with skin melanoma.

Введение. Меланома кожи, несмотря на схожие клинические и гистологические характеристики, может иметь разный прогноз. Профилирование экспрессии генов потенциально позволяет более точно стратифицировать больных по группам риска.

Цель исследования – изучение тест-систем для прогнозирования исходов у пациентов с меланомой кожи на основе анализа первичной опухоли.

Материалы и методы. Проведен систематический обзор литературы (scoping review) в соответствии с принципами PRISMA-ScR. Поиск выполнен в PubMed (2008–2024). В обзор включено 31 исследование из 149 выявленных публикаций. Отбор исследований и анализ данных осуществляли два независимых рецензента для оценки конкордантности. Данные представлены в описательной форме.

Результаты. Оценена эффективность четырех тест-систем, включая наиболее часто используемую DecisionDx-Melanoma (19/31, 61,3 %). Данный тест стратифицирует пациентов по молекулярным классам: у пациентов с высоким риском прогрессирование отмечается в 5,33 (±1,25) раза чаще и сопровождается худшими показателями выживаемости. В проанализированных исследованиях отсутствовали данные по российской популяции.

Заключение. Профилирование экспрессии генов демонстрирует высокую точность в прогнозировании исходов у пациентов с меланомой кожи.

skin melanomagene expression profilingrisk stratificationprognostic test systemsGEP

меланома кожипрофилирование экспрессии геновстратификация рискапрогностические тест-системыGEP

The work was performed as part of the research development 124110100009-5

Работа выполнена в рамках НИР 124110100009-5

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