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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Bone and soft tissue sarcomas, tumors of the skin</journal-id><journal-title-group><journal-title xml:lang="en">Bone and soft tissue sarcomas, tumors of the skin</journal-title><trans-title-group xml:lang="ru"><trans-title>Саркомы костей, мягких тканей и опухоли кожи</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4614</issn><issn publication-format="electronic">2782-3687</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">720</article-id><article-id pub-id-type="doi">10.17650/2219-4614-2024-16-4-43-52</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Brachytherapy in soft tissue sarcomas (literature review)</article-title><trans-title-group xml:lang="ru"><trans-title>Брахитератия при саркомах мягких тканей (обзор литературы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6232-1702</contrib-id><name-alternatives><name xml:lang="en"><surname>Burov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Буров</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Denis Alexandrovich Burov</bold></p><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p><bold>Денис Александрович Буров</bold> </p><p>115522 Москва, Каширское шоссе, 24</p></bio><email>denisburov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5231-9927</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedoseenko</surname><given-names>D. I.</given-names></name><name xml:lang="ru"><surname>Федосеенко</surname><given-names>Д. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8814-8381</contrib-id><name-alternatives><name xml:lang="en"><surname>Petrochenko</surname><given-names>N. S.</given-names></name><name xml:lang="ru"><surname>Петроченко</surname><given-names>Н. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-5456-8836</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0400-3331</contrib-id><name-alternatives><name xml:lang="en"><surname>Salkov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Сальков</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1396-3434</contrib-id><name-alternatives><name xml:lang="en"><surname>Bokhyan</surname><given-names>B. Yu.</given-names></name><name xml:lang="ru"><surname>Бохян</surname><given-names>Б. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4944-4035</contrib-id><name-alternatives><name xml:lang="en"><surname>Chernykh</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Черных</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2038-3729</contrib-id><name-alternatives><name xml:lang="en"><surname>Valiev</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Валиев</surname><given-names>А. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>24 Kashirskoe Shosse, Moscow 115522</p></bio><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 24</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-11-01" publication-format="electronic"><day>01</day><month>11</month><year>2024</year></pub-date><volume>16</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2025-02-01"><day>01</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-02-01"><day>01</day><month>02</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Burov D.A., Fedoseenko D.I., Petrochenko N.S., Kozlov O.V., Salkov A.G., Bokhyan B.Y., Chernykh M.V., Valiev A.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Буров Д.А., Федосеенко Д.И., Петроченко Н.С., Козлов О.В., Сальков А.Г., Бохян Б.Ю., Черных М.В., Валиев А.К.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Burov D.A., Fedoseenko D.I., Petrochenko N.S., Kozlov O.V., Salkov A.G., Bokhyan B.Y., Chernykh M.V., Valiev A.K.</copyright-holder><copyright-holder xml:lang="ru">Буров Д.А., Федосеенко Д.И., Петроченко Н.С., Козлов О.В., Сальков А.Г., Бохян Б.Ю., Черных М.В., Валиев А.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://sarbon.abvpress.ru/jour/article/view/720">https://sarbon.abvpress.ru/jour/article/view/720</self-uri><abstract xml:lang="en"><p>The article presents an analysis of publications on the effectiveness of brachytherapy in the soft tissue sarcomas. It has been shown that this method is an important part of the combined treatment of this pathology and the indications for its use are constantly expanding. The authors point to a high level of local control of the disease (from 50 to 96 % of cases). The greatest effectiveness of brachytherapy is observed in combination with surgical tumor removal.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен анализ публикаций, посвященных эффективности брахитерапии при саркомах мягких тканей. Показано, что этот метод представляет собой важную часть комбинированного лечения данной патологии, а показания к его применению постоянно расширяются. Авторы указывают на высокий уровень локального контроля над заболеванием (от 50 до 96 % случаев). Наибольшая эффективность брахитерапии наблюдается в комбинации с хирургическим удалением опухоли.</p></trans-abstract><kwd-group xml:lang="en"><kwd>soft tissue sarcomas</kwd><kwd>brachytherapy</kwd><kwd>surgical treatment</kwd><kwd>brachytherapy effectiveness</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>саркомы мягких тканей</kwd><kwd>брахитерапия</kwd><kwd>хирургическое лечение</kwd><kwd>эффективность брахитерапиии</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The work was carried out with the financial support of the Russian Science Foundation (grant No. 23-65-00003)</funding-statement><funding-statement xml:lang="ru">Работа выполнена при финансовой поддержке Российского научного фонда (грант № 23-65-00003).</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Lancet 1997;350(9092): 1647–54.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Alekhteyar K.M., Leung D.H., Brennan M.F., Harrison L.B. The effect of combined external beam radiotherapy and brachytherapy on local control and wound complications in patients with high-grade soft tissue sarcomas of the extremity with positive microscopic margin. Int J Radiat Oncol Biol Phys 1996;36(2):321–4. DOI: 10.1016/s0360-3016(96)00331-8</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Alektiar K.M., Brennan M.F., Singer S. Local control comparison of adjuvant brachytherapy to intensity-modulated radiotherapy in primary high-grade sarcoma of the extremity. Cancer 2011;117(14):3229–34. DOI: 10.1002/cncr.25882</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Guzik G., Łyczek J., Kowalik Ł. Surgical resection with adjuvant brachytherapy in soft tissue sarcoma of the extremity – a case report. J Contemp Brachyther 2012;4(4):227–31. DOI: 10.5114/jcb.2012.32557</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Lawrenz J.M., Johnson S.R., Zhu K. et al. Adjuvant radiation after primary resection of atypical lipomatous tumors of the extremity reduces local recurrence but increases complications: a multicenter evaluation. Sarcoma 2022;2022:2091677. DOI: 10.1155/2022/2091677</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Manir K.S., Basu A., Choudhury K.B. et al. Interstitial brachytherapy in soft tissue sarcoma: a 5 years institutional experience with cobalt 60-based high-dose-rate brachytherapy system. J Contemp Brachyther 2018;10(5):431–8. DOI: 10.5114/jcb.2018.78994</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Muhic A., Hovgaard D., Mørk Petersen M. et al. Local control and survival in patients with soft tissue sarcomas treated with limb sparing surgery in combination with interstitial brachytherapy and external radiation. Radiother Oncol 2008;88(3):382–7. DOI: 10.1016/j.radonc.2008.06.002</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Roeder F. Radiation therapy in adult soft tissue sarcoma – current knowledge and future directions: a review and expert opinion. Cancers 2020;12(11):3242. DOI: 10.3390/cancers12113242</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Strohmaier S., Zwierzchowski G. Comparison of (60) Co and (192) Ir sources in HDR brachytherapy. J Contemp Brachytherapy 2011;4: 199–208. DOI: 10.5114/jcb.2011.26471</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Abarca T., Gao Y., Monga V. et al. Improved survival for extremity soft tissue sarcoma treated in high-volume facilities. J Surg Oncol 2018;117(7):1479–86. DOI: 10.1002/jso.25052</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Emory C.L., Montgomery C.O., Potter B.K. et al. Early complications of high-dose-rate brachytherapy in soft tissue sarcoma: a comparison with traditional external-beam radiotherapy. Clin Orthop Relat Res 2012;470(3):751–8. DOI: 10.1007/s11999-011-2106-5</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Casali P.G., Jost L., Sleijfer S. et al. Soft Tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008;19(Suppl. 2):ii89–93. DOI: 10.1093/annonc/mdn101</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>DeLaney T.F., Trofimov A.V., Engelsman M., Suit H.D. Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas. Cancer Control 2005;12(1):27–35. DOI: 10.1177/107327480501200104</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Ghadimi M.P.H., Rehders A., Knoefel W.T. Multimodal management in soft tissue sarcoma of the trunk and extremities. Chirurg 2014;85(5):378–82. DOI: 10.1007/s00104-013-2690-x</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Martínez-Monge R., San Julián M., Amillo S. et al. Perioperative highdose-rate brachytherapy in soft tissue sarcomas of the extremity and superficial trunk in adults: initial results of a pilot study. Brachytherapy 2005;4(4):264–70. DOI: 10.1016/j.brachy.2005.06.003</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Gimeno M., San Julián M., Cambeiro M. et al. Long-term results of perioperative high dose rate brachytherapy (PHDRB) and external beam radiation in adult patients with soft tissue sarcomas of the extremities and the superficial trunk: final results of a prospective controlled study. Radiother Oncol 2019;135:91–9. DOI: 10.1016/j.radonc.2019.02.011</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Mariani L., Miceli R., Kattan M.W. et al. Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system. Cancer 2005;103(2):402–8. DOI: 10.1002/cncr.20778</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Miller E.D., Xu-Welliver M., Haglund K.E. The role of modern radiation therapy in the management of extremity sarcomas. J Surg Oncol 2015;111(5):599–603. DOI: 10.1002/jso.23823</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Burningham Z., Hashibe M., Spector L., Schiffman J.D. The epidemiology of sarcoma. Clin Sarcoma Res 2012;2(1):14. DOI: 10.1186/2045-3329-2-14</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Fontanesi J., Mott M.P., Lucas D.R. et al. The role of irradiation in the management of locally recurrent non-metastatic soft tissue sarcoma of extremity/trunkal locations. Sarcoma 2004;8(2–3):57–61. DOI: 10.1080/13577140412331332785</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Klein J., Ghasem A., Huntley S. et al. Does an algorithmic approach to using brachytherapy and external beam radiation result in good function, local control rates, and low morbidity in patients with extremity soft tissue sarcoma? Clin Orthop Relat Res 2018;476(3):634–44. DOI: 10.1007/s11999.0000000000000079</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Roeder F., Lehner B., Saleh-Ebrahimi L. et al. Intraoperative electron radiation therapy combined with external beam radiation therapy and limb sparing surgery in extremity soft tissue sarcoma: a retrospective single center analysis of 183 cases. Radiother Oncol 2016;119(1):22–9. DOI: 10.1016/j.radonc.2015.11.014</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Maples W.J., Buskirk S.J. Multimodality treatment of upper extremity bone and soft tissue sarcomas. Hand Clin 2004;20(2):221–5. DOI: 10.1016/j.hcl.2004.03.021</mixed-citation></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Tskhovrebov E.E., Bogdanov Yu.M., Suslova V.A. Brachytherapy in the complex treatment of soft tissue sarcomas. Diagnostic and Interventional radiology 12(2 Appendix No. 1);21–2. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Цховребов Е.Е., Богдаев Ю.М., Суслова В.А. Брахитерапия в комплексном лечении сарком мягких тканей. Диагностическая и интервенционная радиология 12(2 Приложение № 1);21–2.</mixed-citation></citation-alternatives></ref><ref id="B25"><label>25.</label><mixed-citation>Arifi S., Belbaraka R., Rahhali R., Ismaili N. Treatment of adult soft tissue sarcomas: an overview. Rare Cancers Ther 2015;3(1):69–87. DOI: 10.1007/s40487-015-0011-x</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Laskar S., Bahl G., Puri A. et al. Perioperative interstitial brachytherapy for soft tissue sarcomas: prognostic factors and long-term results of 155 patients. Ann Surg Oncol 2007;14(2):560–7. DOI: 10.1245/s10434-006-9137-2</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Aronowitz J.N., Pohar S.S., Liu L. et al. Adjuvant high dose rate brachytherapy in the management of soft tissue sarcoma: a dose-toxicity analysis. Am J Clin. Oncol 2006;29(5):508–13. DOI: 10.1097/01.coc.0000231433.97407.c8</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Daigeler A., Zmarsly I., Hirsch T. et al. Long-term outcome after local recurrence of soft tissue sarcoma: a retrospective analysis of factors predictive of survival in 135 patients with locally recurrent soft tissue sarcoma. Br J Cancer 2014;110(6):1456–64. DOI: 10.1038/bjc.2014.21</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Fontanesi J., Mott M.P., Kraut M.J. et al. The role of postoperative irradiation in the treatment of locally recurrent incompletely resected extra-abdominal desmoid tumors. Sarcoma 2004;8(2–3):83–6. DOI: 10.1080/13577140410001710512</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Larrier N.A., Czito B.G., Kirsch D.G. Radiation therapy for soft tissue sarcoma: indications and controversies for neoadjuvant therapy, adjuvant therapy, intraoperative radiation therapy, and brachytherapy. Surg Oncol Clin N Am 2016;25(4):841–60. DOI: 10.1016/j.soc.2016.05.012</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Pasquali S., Palassini E., Stacchiotti S. et al. Neoadjuvant treatment: a novel standard? Curr Opin Oncol 2017;29(4):253–9. DOI: 10.1097/CCO.0000000000000372</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Röper B., Heinrich C., Kehl V. et al. Study of preoperative radiotherapy for sarcomas of the extremities with intensity-modulation, imagguidance and small safety-margins (PREMISS). BMC Cancer 2015;15:904. DOI: 10.1186/s12885-015-1633-y</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Spoto R., Vavassori A., Dicuonzo S. et al. Adjuvant radiotherapy treatment for soft tissue sarcoma of extremities and trunk. A retrospective mono-institutional analysis. Neoplasma 2020;67(6):1447–55. DOI: 10.4149/neo_2020_200325N305</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Llacer C., Delannes M., Minsat M. et al. Low-dose intraoperative brachytherapy in soft tissue sarcomas involving neurovascular structure. Radiother Oncol 2006;78(1):10–6. DOI: 10.1016/j.radonc.2005.12.002</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Naghavi A.O., Fernandez D.C., Mesko N. et al. American brachytherapy society consensus statement for soft tissue sarcoma brachytherapy. Brachytherapy 2017;16(3):466–89. DOI: 10.1016/j.brachy.2017.02.004</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Alektiar K.M., Leung D., Zelefsky M.J. et al. Adjuvant brachytherapy for primary high-grade soft tissue sarcoma of the extremity. Ann Surg Oncol 2002;9(1):48–56. DOI: 10.1245/aso.2002.9.1.48</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Beltrami G., Rüdiger H.A., Mela M.M. et al. Limb salvage surgery in combination with brachytherapy and external beam radiation for high-grade soft tissue sarcomas. Eur J Surg Oncol 2008;34(7):811–6. DOI: 10.1016/j.ejso.2007.08.011</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Cortesi A., Galuppi A., Frakulli R. et al. Adjuvant radiotherapy with brachytherapy boost in soft tissue sarcomas. J Contemp Brachyther 2017;9(3):256–62. DOI: 10.5114/jcb.2017.68215</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Kaushal A., Citrin D. The role of radiation therapy in the management of sarcomas. Surg Clin N Am 2008;88(3):629–46. DOI: 10.1016/j.suc.2008.03.005</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Lazzaro G., Lazzari R., Pelosi G. et al. Pulsed dose-rate perioperative interstitial brachytherapy for soft tissue sarcomas of the extremities and skeletal muscles of the trunk. Ann Surg Oncol 2005;12(11):935–42. DOI: 10.1245/ASO.2005.11.004</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Nandra R., Hwang N., Matharu G. et al. One-year mortality in patients with bone and soft tissue sarcomas as an indicator of delay in presentation. Ann R Coll Surg Engl 2015;97(6):425–33. DOI: 10.1308/003588415X14181254790284</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Potter J.W., Jones K.B., Barrott J.J. Sarcoma – the standard-bearer in cancer discovery. Crit Rev Oncol Hematol 2018;126:1–5. DOI: 10.1016/j.critrevonc.2018.03.007</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Alektiar K.M., Zelefsky M.J., Brennan M.F. Morbidity of adjuvant brachytherapy in soft tissue sarcoma of the extremity and superficial trunk. Int J Radiat Oncol Biol Phys 2000;47(5):1273–9. DOI: 10.1016/s0360-3016(00)00587-3</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Correa R., Gómez-Millán J., Lobato M. et al. Radiotherapy in soft-tissue sarcoma of the extremities. Clin Transl Oncol 2018;20(9):1127–35. DOI: 10.1007/s12094-018-1848-x</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Kretzler A., Molls M., Gradinger R. et al. Intraoperative radiotherapy of soft tissue sarcoma of the extremity. Strahlenther Onkol 2004;180(6):365–70. DOI: 10.1007/s00066-004-1191-8</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Moureau-Zabotto L., Thomas L., Bui B.N. et al. Management of soft tissue sarcomas (STS) in first isolated local recurrence: a retrospective study of 83 cases. Radiother Oncol 2004;73(3):313–9. DOI: 10.1016/j.radonc.2004.05.008</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Naghavi A.O., Gonzalez R.J., Scott J.G. et al. Implications of staged reconstruction and adjuvant brachytherapy in the treatment of recurrent soft tissue sarcoma. Brachytherapy 2016;15(4):495–503. DOI: 10.1016/j.brachy.2016.03.013</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Delaney T.F. Radiation therapy: neoadjuvant, adjuvant, or not at all. Surg Oncol Clin N Am 2012;21(2):215–41. DOI: 10.1016/j.soc.2011.12.005</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Sarria G.R., Petrova V., Wenz F. et al. Intraoperative radiotherapy with low energy x-rays for primary and recurrent soft-tissue sarcomas. Radiat Oncol 2020;15(1):110. DOI: 10.1186/s13014-020-01559-7</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Bradley J.A., Kleinman S.H., Rownd J. et al. Adjuvant high dose rate brachytherapy for soft tissue sarcomas: initial experience report. J Contemp Brachyther 2011;3(1):3–10. DOI: 10.5114/jcb.2011.21036</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Shukla N.K., Deo S.V.S. Soft tissue sarcoma – review of experience at a tertiary care cancer centre. Indian J Surg Oncol 2011;2(4):309–12. DOI: 10.1007/s13193-011-0119-x</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Healey J.H. CORR insights®: does an algorithmic approach to using brachytherapy and external beam radiation result in good function, local control rates, and low morbidity in patients with extremity soft tissue sarcoma? Clin Orthop Relat Res 2018;476(3):645–7. DOI: 10.1007/s11999.0000000000000184</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Ren C., Shi R., Min L. et al. Experience of interstitial permanent i125 brachytherapy for extremity soft tissue sarcomas. Clin Oncol 2014;26(4):230–5. DOI: 10.1016/j.clon.2014.01.004</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Torres M.A., Ballo M.T., Butler C.E. et al. Management of locally recurrent soft-tissue sarcoma after prior surgery and radiation therapy. Int J Radiat Oncol Biol Phys 2007;67(4):1124–9. DOI: 10.1016/j.ijrobp.2006.10.036</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Kattan M.W., Leung D.H.Y., Brennan M.F. Postoperative nomogram for 12-year sarcoma-specific death. JCO 2002;20(3):791–6. DOI: 10.1200/JCO.2002.20.3.791</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>San Miguel I., San Julian M., Cambeiro M. et al. Determinants of toxicity, patterns of failure, and outcome among adult patients with soft tissue sarcomas of the extremity and superficial trunk treated with greater than conventional doses of perioperative high-doserate brachytherapy and external beam radiotherapy. Int J Radiat Oncol Biol Phys 2011;81(4):529–39. DOI: 10.1016/j.ijrobp.2011.04.063</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Atean I., Pointreau Y., Rosset P. et al. Prognostic factors of extremity soft tissue sarcoma in adults. A single institutional analysis. Cancer Radiother 2012;16(8):661–6. DOI: 10.1016/j.canrad.2012.05.021</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Mierzwa L.M., McCluskey C.M., Barrett W.L. et al. Interstitial brachytherapy for soft tissue sarcoma: a single institution experience. Brachytherapy 2007;6(4):298–303. DOI: 10.1016/j.brachy.2007.08.004</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Alektiar K.M., Hong, L., Brennan M.F. et al. Intensity modulated radiation therapy for primary soft tissue sarcoma of the extremity: preliminary results. Int J Radiat Oncol Biol Phys 2007;68(2):458–64. DOI: 10.1016/j.ijrobp.2006.12.054</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Rimner A., Brennan M.F., Zhang Z. et al. Influence of compartmental involvement on the patterns of morbidity in soft tissue sarcoma of the thigh. Cancer 2009;115(1):149–57. DOI: 10.1002/cncr.23975</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Rudert M., Burgkart R., Gradinger R., Rechl H. Surgical treatment of musculoskeletal soft tissue sarcomas. Chirurg 2009;80(3):194–201. DOI: 10.1007/s00104-008-1595-6</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Mukherji A., Sinnatamby M. Malignant soft tissue sarcoma of the shoulder treated by surface mould brachytherapy boost in an adjuvant setting. J Contemp Brachyther 2017;9(2):167–73. DOI: 10.5114/jcb.2017.67392</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Petera J., Soumarová R., Růzicková J. et al. Perioperative hyperfractionated high-dose rate brachytherapy for the treatment of soft tissue sarcomas: multicentric experience. Ann Surg Oncol 2010;17(1):206–10. DOI: 10.1245/s10434-009-0684-1</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Murray P.M. Soft tissue sarcoma of the upper extremity. Hand Clin 2004;20(3):325–33. DOI: 10.1016/j.hcl.2004.03.007</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Vavassori A., Pennacchioli E., Augugliaro M. et al. Adjuvant high-dose-rate interstitial brachytherapy for malignant peripheral nerve sheath tumor of the foot: a case report. J Contemp Brachyther 2021;13(3):338–46. DOI: 10.5114/jcb.2021.106204</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Baumert B.G., Infanger M., Reiner B., Davis J.B. A novel technique using customised templates for the application of fractionated interstitial HDR brachytherapy to the tumour bed in soft-tissue sarcomas located in the extremities. Clin Oncol 2004;16(7):457–60. DOI: 10.1016/j.clon.2004.06.020</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Rachbauer F., Sztankay A., Kreczy A. et al. High-dose-rate intraoperative brachytherapy (IOHDR) using flab technique in the treatment of soft tissue sarcomas. Strahlenther Onkol 2003;179(7):480–5. DOI: 10.1007/s00066-003-1063-7</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Schuetze M.S., Ray M.E. Adjuvant therapy for soft tissue sarcoma. J Natl Compr Cancer Netw 2005;3(2):207–13. DOI: 10.6004/jnccn.2005.0013</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Schneider F., Clausen S., Thölking J. et al. A novel approach for superficial intraoperative radiotherapy (IORT) using a 50 KV x-ray source: a technical and case report. J Appl Clin Med Phys 2014;15(1):167–76. DOI: 10.1120/jacmp.v15i1.4502</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Ballo M.T., Lee A.K. current results of brachytherapy for soft tissue sarcoma. Curr Opin Oncol 2003;15(4):313–8. DOI: 10.1097/00001622-200307000-00006</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Roeder F., Krempien R. Intraoperative radiation therapy (IORT) in soft-tissue sarcoma. Radiat Oncol 2017;12(1):20. DOI: 10.1186/s13014-016-0751-2</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Mccarter M.D., Jaques D.P., Brennan M.F. Randomized clinical trials in soft tissue sarcoma. Surg Oncol Clin N Am 2002;11(1):11–22. DOI: 10.1016/s1055-3207(03)00073-5</mixed-citation></ref></ref-list></back></article>
