Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press74910.17650/2219-4614-2025-17-2-73-82SOFT TISSUE SARCOMASСАРКОМЫ МЯГКИХ ТКАНЕЙModern criteria for assessing the therapeutic pathomorphosis of synovial sarcoma: clinical significance and outcome predictionСовременные критерии оценки лечебного патоморфоза синовиальной саркомы: клиническое значение и прогнозирование исходовhttps://orcid.org/0009-0007-0930-5272MakhachevD. R.МахачевД. Р.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

Далгат Рамазанович Махачев

117513 Москва, ул. Островитянова, 1

dalgat2002@mail.ruhttps://orcid.org/0009-0005-3772-6643BulanovD. V.БулановД. В.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0009-4294-8557AmetovD. M.АметовД. М.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0002-3305-7903AbakarovM. O.АбакаровМ. О.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0003-9353-5150AbacharaevaA. R.АбачараеваА. Р.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0000-5790-2062BagandovaP. A.БагандоваП. А.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0007-4725-8307GabibullaevR. M.ГабибуллаевР. М.
Russian Federation

1 Ostrovityanova St., Moscow 117513,

117513 Москва, ул. Островитянова, 1

https://orcid.org/0009-0009-6778-0519DzhanborievA. D.ДжанбориевА. Д.
Russian Federation

10 Studencheskaya St., Voronezh 394036

394036 Воронеж, ул. Студенческая, 10

N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииN.N. Burdenko Voronezh State Medical University, Ministry of Health of RussiaФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России2507202517273822507202525072025Copyright ©; 2025, Makhachev D.R., Bulanov D.V., Ametov D.M., Abakarov M.O., Abacharaeva A.R., Bagandova P.A., Gabibullaev R.M., Dzhanboriev A.D.Copyright ©; 2025, Махачев Д.Р., Буланов Д.В., Аметов Д.М., Абакаров М.О., Абачараева А.Р., Багандова П.А., Габибуллаев Р.М., Джанбориев А.Д.2025Makhachev D.R., Bulanov D.V., Ametov D.M., Abakarov M.O., Abacharaeva A.R., Bagandova P.A., Gabibullaev R.M., Dzhanboriev A.D.Махачев Д.Р., Буланов Д.В., Аметов Д.М., Абакаров М.О., Абачараева А.Р., Багандова П.А., Габибуллаев Р.М., Джанбориев А.Д.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/749

Synovial sarcoma is a rare malignant soft tissue tumor characterized by high aggressiveness and a propensity for metastasis. The assessment of therapeutic pathomorphosis plays a crucial role in predicting disease outcomes and selecting the optimal treatment strategy. This article discusses the morphological and molecular characteristics of synovial sarcoma, existing classifications of pathomorphosis, modern assessment methods, and the prognostic significance of pathomorphosis degree. Special attention is given to the impact of various factors on treatment efficacy, the prospects of personalized medicine, and the integration of innovative technologies in the diagnosis and management of this tumor.

Синовиальная саркома представляет собой редкую злокачественную опухоль мягких тканей, характеризующуюся высокой агрессивностью и склонностью к метастазированию. Оценка лечебного патоморфоза играет ключевую роль в прогнозировании исходов заболевания и выборе оптимальной тактики терапии. В данной статье рассматриваются морфологические и молекулярные особенности синовиальной саркомы, существующие классификации патоморфоза, современные методы его оценки, а также прогностическая значимость степени патоморфоза. Особое внимание уделяется влиянию различных факторов на эффективность терапии, перспективам персонализированной медицины и внедрению инновационных технологий в диагностику и лечение данной опухоли.

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