Bone and soft tissue sarcomas, tumors of the skinBone and soft tissue sarcomas, tumors of the skinСаркомы костей, мягких тканей и опухоли кожи2219-46142782-3687Publishing House ABV Press76210.17650/2219-4614-2025-17-3-26-37REVIEWSОБЗОРНЫЕ СТАТЬИSynovial sarcoma: current view of pathogenesis and therapeutic approachesСиновиальная саркома: современный взгляд на основы патогенеза и терапевтические подходыhttps://orcid.org/0000-0002-9921-5620SenchenkoM. A.СенченкоМ. А.
Russian Federation

 24  Kashirskoe Shosse,  Moscow  115522

115522  Москва,  Каширское шоссе,  24

117997  Москва,  ул. Саморы  Машела,  1

https://orcid.org/0000-0002-5548-3295TararykovaA. A.ТарарыковаА. А.
Russian Federation

24  Kashirskoe Shosse,  Moscow  115522

115522  Москва,  Каширское шоссе,  24

https://orcid.org/0000-0003-3852-3969KozlovN. A.КозловН. А.
Russian Federation

24  Kashirskoe Shosse,  Moscow  115522

115522  Москва,  Каширское шоссе,  24

https://orcid.org/0000-0002-5082-9883FetisovT.  I. ФетисовТ. И.
Russian Federation

6  Miklukho-Maklaya  St.,  Moscow  117198

117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0000-0002-8599-6833KirsanovK. I. КирсановК. И.
Russian Federation

6  Miklukho-Maklaya  St.,  Moscow  117198

117198 Москва, ул. Миклухо-Маклая, 6

https://orcid.org/0000-0003-0777-9152RogozhinD.  V. РогожинД. В.
Russian Federation

Dmitry Viktorovich Rogozhin

24  Kashirskoe Shosse,  Moscow  115522

1 Ostrovityanova St., 117513 Moscow

Дмитрий Викторович Рогожин 

115522  Москва,  Каширское шоссе,  24

117513  Москва,  ул. Островитянова,  1

pathol.777@mail.ruN.N.  Blokhin  National  Medical  Research  Center  of  Oncology,  Ministry  of  Health of  RussiaФГБУ  «Национальный  медицинский  исследовательский центр  онкологии  им.  Н.  Н.  Блохина»  Минздрава  РоссииDmitry  Rogachev  National  Medical Research  Center  of  Pediatric  Hematology,  Oncology  and  Immunology,  Ministry  of  Health  of  RussiaФГБУ  «Национальный  медицинский  исследовательский центр  детской  гематологии,  онкологии  и  иммунологии   им.  Дмитрия  Рогачева»  МинздраваRUDN  UniverstiyФГАОУ  ВО  «Российский  университет  дружбы  народов  им. Патриса  Лумумбы»Pirogov  Russian  National  Research  Medical  University,  Ministry  of Health  of  RussiaФГАОУ  ВО  «Российский  национальный  исследовательский  медицинский  университет  им.  Н. И.  Пирогова»  Минздрава  России1410202517326371410202514102025Copyright ©; 2025, Senchenko M.A., Tararykova A.A., Kozlov N.A., Fetisov T.I., Kirsanov K.I., Rogozhin D.V.Copyright ©; 2025, Сенченко М.А., Тарарыкова А.А., Козлов Н.А., Фетисов Т.И., Кирсанов К.И., Рогожин Д.В.2025Senchenko M.A., Tararykova A.A., Kozlov N.A., Fetisov T.I., Kirsanov K.I., Rogozhin D.V.Сенченко М.А., Тарарыкова А.А., Козлов Н.А., Фетисов Т.И., Кирсанов К.И., Рогожин Д.В.https://creativecommons.org/licenses/by/4.0https://sarbon.abvpress.ru/jour/article/view/762

 Synovial sarcoma is characterized by a typical transcript SS18::SSX. However, despite a common pathogenesis  and similar therapeutic approaches, opposite responses to therapy are sometimes observed. Supposedly, this can be associated with additional and alternative pathways of genetic and epigenetic regulation. In this review, the problems of synovial sarcoma  diagnosis, pathogenesis and new therapy methods, including targeting epigenetics, are discussed.

Синовиальная саркома характеризуется типичным транскриптом SS18::SSX. Несмотря на общий патогенез и одинаковые терапевтические подходы, может отмечаться разнонаправленный характер ответа на проводимую терапию. Предположительно это может быть связано с дополнительными, альтернативными путями генетической и эпигенетической регуляции. В настоящем обзоре рассмотрены вопросы диагностики, патогенеза и новые методы терапии синовиальной саркомы, в том числе эпигенетически направленные.

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